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Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and environmental variation. However, even genetically identical cells in identical environments display variable phenotypes. Stochastic gene expression, or gene expression "noise," has been suggested as a major source of this variability, and its physiological consequences have been topics of intense res...
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Robust adaptive estimation of unknown parameter has been an important issue in recent years for reliable operation in the distributed networks. The conventional adaptive estimation algorithms that rely on mean square error (MSE) criterion exhibit good performance in the presence of Gaussian noise, but their performance drastically decreases under impulsive noise. In this paper, we propose a rob...
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Simulations and analysis in the previous chapter are based on parameters for the λ cI system. Here, we test those predictions experimentally by building a synthetic circuit using the λ cI repressor and other characterized circuit elements in E. coli bacteria. The synthetic circuit uses three fluorescent proteins so that noisy gene expression can be monitored with time-lapse microscopy. To apply...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2016
ISSN: 0960-9822
DOI: 10.1016/j.cub.2015.12.002